Generation of Homogeneous PDX1+ Pancreatic Progenitors from Human ES Cell-derived Endoderm Cells

One key step in producing insulin-secreting cells from human embryonic stem (hES) cells is the generation of pancreatic and duodenal homeobox gene 1 (PDX1)-expressing pancreatic progenitor cells. All-trans retinoic acid (RA) has important roles in pancreas development and is widely used to induce pa...

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Veröffentlicht in:	Journal of molecular cell biology 2010-02, Vol.2 (1), p.50-60
Hauptverfasser:	Cai, Jun, Yu, Chen, Liu, Yanxia, Chen, Song, Guo, Yuxuan, Yong, Jun, Lu, Wei, Ding, Mingxiao, Deng, Hongkui
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Culture Techniques Cell Differentiation Cells, Cultured Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Endoderm - cytology Endoderm - metabolism Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Humans Insulin-Secreting Cells - cytology Insulin-Secreting Cells - metabolism Pancreas - cytology Pancreas - metabolism Trans-Activators - genetics Trans-Activators - metabolism Tretinoin - metabolism
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Beschreibung
Zusammenfassung:	One key step in producing insulin-secreting cells from human embryonic stem (hES) cells is the generation of pancreatic and duodenal homeobox gene 1 (PDX1)-expressing pancreatic progenitor cells. All-trans retinoic acid (RA) has important roles in pancreas development and is widely used to induce pancreatic differentiation of ES cells. When RA was added directly to the activin A-induced hES cells,
ISSN:	1674-2788 1759-4685
DOI:	10.1093/jmcb/mjp037