Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N-acetylcysteine

Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N-acetylcysteine

Electrochemical oxidation of acetaminophen has been studied in the presence of glutathione and acetylcysteine. Our results indicate that N-acetyl-p-benzoquinone-imine (NAPQI) participates in a catalytic reaction with glutathione and N-acetylcysteine. Also, the observed homogeneous rate constants of...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2010-01, Vol.46 (3), p.409-411
Hauptverfasser: Shayani-Jam, Hasan, Nematollahi, Davood
Format: Artikel
Sprache:eng
Schlagworte:
Acetaminophen - chemistry
Acetylcysteine - chemistry
Analgesics, Non-Narcotic - chemistry
Electrochemistry
Glutathione - chemistry
Oxidation-Reduction
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Zusammenfassung:Electrochemical oxidation of acetaminophen has been studied in the presence of glutathione and acetylcysteine. Our results indicate that N-acetyl-p-benzoquinone-imine (NAPQI) participates in a catalytic reaction with glutathione and N-acetylcysteine. Also, the observed homogeneous rate constants of the reaction of NAPQI with glutathione and acetylcysteine were estimated.
ISSN:1359-7345
1364-548X
DOI:10.1039/b916458h