Tumor-specific Correlation of Tumour M2 Pyruvate Kinase in Pre-Invasive, Invasive and Recurrent Cervical Cancer

The aim of this study was to investigate the diagnostic value of tumor M2 pyrurate kinase (Tu-M2-PK) as a tumor marker in patients with pre-invasive (CIN), invasive (PCC) and recurrent (RCC) cervical cancer. Plasma samples were investigated from 125 patients, comprising 50 cases of CIN (I-III), 51 o...

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Veröffentlicht in:	Anticancer research 2010-02, Vol.30 (2), p.375-381
Hauptverfasser:	LANDT, Solveig, JESCHKE, Sophia, SEHOULI, Jalid, KUEMMEL, Sherko, KOENINGER, Angela, THOMAS, Anke, HEUSNER, Till, KORLACH, Susanne, ULM, Kurt, SCHMIDT, Peter, BLOHMER, Jens-Uwe, LICHTENEGGER, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - blood Adenocarcinoma - enzymology Adenocarcinoma - secondary Adult Aged Aged, 80 and over Antigens, Neoplasm - blood Biological and medical sciences Biomarkers, Tumor - blood Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - secondary Cervical Intraepithelial Neoplasia - blood Cervical Intraepithelial Neoplasia - diagnosis Cervical Intraepithelial Neoplasia - enzymology Cervix Uteri - metabolism Enzyme-Linked Immunosorbent Assay Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - blood Neoplasm Recurrence, Local - diagnosis Neoplasm Recurrence, Local - enzymology Prognosis Pyruvate Kinase - blood Serpins - blood Tumors Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - enzymology Young Adult
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Zusammenfassung:	The aim of this study was to investigate the diagnostic value of tumor M2 pyrurate kinase (Tu-M2-PK) as a tumor marker in patients with pre-invasive (CIN), invasive (PCC) and recurrent (RCC) cervical cancer. Plasma samples were investigated from 125 patients, comprising 50 cases of CIN (I-III), 51 of PCC (FIGO I-IV) and 24 of RCC, before treatment. Tu-M2-PK levels were determined by using a quantitative sandwich enzyme immunoassay. With the increase in disease severity from CIN to PCC to RCC, levels of Tu-M2-PK significantly increased (p
ISSN:	0250-7005 1791-7530