Treg and lupus

Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms. In addition novel subsets of Treg might ar...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Annals of the rheumatic diseases 2010-01, Vol.69 (Suppl 1), p.i65-i66
Hauptverfasser:	Bonelli, M, Smolen, J S, Scheinecker, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmune diseases Autoimmune Diseases - immunology Cell growth Disease Humans Immunology Lupus Lupus Erythematosus, Systemic - immunology Lymphocytes T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocytes, Regulatory - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Autoimmune diseases such as systemic lupus erythemathodes (SLE) display quantitative and/or qualitative deficiencies of CD4+CD25+ regulatory T cells (Treg). This might contribute to the immune dysregulation and break-down of peripheral tolerance mechanisms. In addition novel subsets of Treg might arise under specific autoimmune conditions as an effort to counteract autoimmunity. Advances in our understanding of how to characterise and manipulate Treg in patients with autoimmune diseases are required in order to develop new therapeutic strategies.
ISSN:	0003-4967 1468-2060
DOI:	10.1136/ard.2009.117135