Biosynthesis: unmasking morphine
The final steps in the biosynthetic pathway to the morphine alkaloids have been revealed with the characterization of two key enzymes. In addition to the widely exploited parent compound, these new O-demethylases control metabolic flux to pharmaceutically useful opioid precursors. [PUBLICATION ABSTR...
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| Veröffentlicht in: | Nature chemical biology 2010-04, Vol.6 (4), p.251-252 |
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| container_title | Nature chemical biology |
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| creator | Dimise, Eric J Bruner, Steven D |
| description | The final steps in the biosynthetic pathway to the morphine alkaloids have been revealed with the characterization of two key enzymes. In addition to the widely exploited parent compound, these new O-demethylases control metabolic flux to pharmaceutically useful opioid precursors. [PUBLICATION ABSTRACT] |
| doi_str_mv | 10.1038/nchembio.334 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 1552-4450 |
| ispartof | Nature chemical biology, 2010-04, Vol.6 (4), p.251-252 |
| issn | 1552-4450 1552-4469 |
| language | eng |
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| source | MEDLINE; Springer Nature - Connect here FIRST to enable access; SpringerLink (Online service) |
| subjects | Biochemistry Biosynthesis Chemical compounds Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP1A2 - metabolism Dioxygenases - metabolism Enzymes Humans Metabolism Methylation Molecular Conformation Morphine - biosynthesis Morphine - chemistry Morphine - metabolism Narcotics |
| title | Biosynthesis: unmasking morphine |
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