Biosynthesis Unmasking morphine

The final steps in the biosynthetic pathway to the morphine alkaloids have been revealed with the characterization of two key enzymes. In addition to the widely exploited parent compound, these new O-demethylases control metabolic flux to pharmaceutically useful opioid precursors. [PUBLICATION ABSTR...

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Veröffentlicht in:	Nature chemical biology 2010-04, Vol.6 (4), p.251-252
Hauptverfasser:	Bruner, Steven D, Dimise, Eric J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biosynthesis Chemical compounds Cytochrome P-450 CYP1A2 - genetics Cytochrome P-450 CYP1A2 - metabolism Dioxygenases - metabolism Enzymes Humans Metabolism Methylation Molecular Conformation Morphine - biosynthesis Morphine - chemistry Morphine - metabolism Narcotics
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Zusammenfassung:	The final steps in the biosynthetic pathway to the morphine alkaloids have been revealed with the characterization of two key enzymes. In addition to the widely exploited parent compound, these new O-demethylases control metabolic flux to pharmaceutically useful opioid precursors. [PUBLICATION ABSTRACT]
ISSN:	1552-4450 1552-4469
DOI:	10.1038/nchembio.334