Mean platelet volume predicts early death in acute pulmonary embolism

BackgroundRecently, mean platelet volume (MPV) was reported to predict venous thromboembolism. Moreover, MPV correlates with platelet reactivity and indicates poor outcome in acute coronary syndromes.ObjectiveTo examine the hypothesis that in acute pulmonary embolism (APE) MPV is elevated and may pr...

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Veröffentlicht in:	Heart (British Cardiac Society) 2010-03, Vol.96 (6), p.460-465
Hauptverfasser:	Kostrubiec, Maciej, Łabyk, Andrzej, Pedowska-Włoszek, Justyna, Hrynkiewicz-Szymańska, Anna, Pacho, Szymon, Jankowski, Krzysztof, Lichodziejewska, Barbara, Pruszczyk, Piotr
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute coronary syndromes Acute Disease Adult Aged Anticoagulants Atherosclerosis Biological and medical sciences Blood platelets Blood Platelets - pathology Cardiology. Vascular system Embolisms Female Heart attacks Humans Laboratories Male Mean platelet volume Medical sciences Middle Aged Molecular weight Mortality Pathogenesis Platelet Activation platelets Pneumology Prognosis Pulmonary arteries pulmonary embolism Pulmonary Embolism - blood Pulmonary Embolism - complications Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases risk satisfaction Studies Survival Analysis Thromboembolism Thromboembolism - blood Thromboembolism - complications Troponin - blood Variance analysis Ventricular Dysfunction, Right - blood Ventricular Dysfunction, Right - etiology
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Zusammenfassung:	BackgroundRecently, mean platelet volume (MPV) was reported to predict venous thromboembolism. Moreover, MPV correlates with platelet reactivity and indicates poor outcome in acute coronary syndromes.ObjectiveTo examine the hypothesis that in acute pulmonary embolism (APE) MPV is elevated and may predict mortality.Methods and resultsThe study included consecutive 192 patients with APE, (79M/113F, 64±18 years) and 100 controls matched for age, sex and concomitant diseases. On admission blood samples were collected for MPV and troponin measurements. Although MPV did not differ between patients with APE and controls (10.0±1.2 vs 10.1±0.8 fl), it differed between low- and intermediate- or high-risk APE (9.4±1.2 fl, 10.3±1.1 fl, 10.3±1.8 fl; respectively, p
ISSN:	1355-6037 1468-201X
DOI:	10.1136/hrt.2009.180489