The Role of B6-Deficiency in the Tryptophane-Niacin Relationships in Rats

The Role of B6-Deficiency in the Tryptophane-Niacin Relationships in Rats

The omission of pyridoxine from the diet of rats results in a progressive decrease in the urinary excretion of N1-methylnicotinamide after doses of tryptophane. This defect is only slightly overcome by the restoration of pyridoxine to the diet. The data indicate that the abnormal formation of xanthu...

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Veröffentlicht in:The Journal of nutrition 1947-05, Vol.33 (5), p.561-567
Hauptverfasser: Rosen, Fred, Huff, J.W., Perlzweig, W.A.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Niacin - metabolism
Old Medline
Pyridoxine
Rats
Tryptophan - metabolism
Vitamin B 6 Deficiency
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Zusammenfassung:The omission of pyridoxine from the diet of rats results in a progressive decrease in the urinary excretion of N1-methylnicotinamide after doses of tryptophane. This defect is only slightly overcome by the restoration of pyridoxine to the diet. The data indicate that the abnormal formation of xanthurenic acid in B6 deficiency is not responsible for the impaired tryptophane to niacin transformation.
ISSN:0022-3166
DOI:10.1093/jn/33.5.561