Toxicity and Influence of Streptomycin in Breeding of Mice

Summary No toxic effects were observed in albino mice fed streptomycin at daily levels of 1000, 400, 200, 100, and 50 μg for periods of one to 6 months. These levels had no significant influence on percentage fertility, litter size, number of young mice weaned, and general condition of the animals. Although no influence was evident at the various levels of streptomycin in the weight gains of first litters of mice, a greater increase in weight occurred in second litters at higher levels compared to second litters of the control and 50 μg groups.