The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance

Intestinal FGF19 has emerged as a novel endocrine regulator of hepatic bile salt and lipid metabolism. In patients with nonalcoholic fatty liver disease (NAFLD) hepatic lipid metabolism is deranged. A possible role of FGF19 in NAFLD has not been reported yet. In this study, we assessed intestinal FG...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2010-03, Vol.298 (3), p.G440-G445
Hauptverfasser:	Schreuder, Tim C M A, Marsman, Hendrik A, Lenicek, Martin, van Werven, Jochem R, Nederveen, Aart J, Jansen, Peter L M, Schaap, Frank G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Area Under Curve Bile Bile Acids and Salts - blood Bile Acids and Salts - metabolism Cholestenones - blood Cholestenones - metabolism Dietary Fats - metabolism Drug resistance Fatty Liver - blood Fatty Liver - metabolism Female Fibroblast Growth Factors - blood Fibroblast Growth Factors - metabolism Humans Insulin Insulin Resistance - physiology Intestines - metabolism Lipids Liver - metabolism Liver diseases Male Metabolism Middle Aged Patients Postprandial Period - physiology Triglycerides - blood Triglycerides - metabolism
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