The hepatic response to FGF19 is impaired in patients with nonalcoholic fatty liver disease and insulin resistance

Intestinal FGF19 has emerged as a novel endocrine regulator of hepatic bile salt and lipid metabolism. In patients with nonalcoholic fatty liver disease (NAFLD) hepatic lipid metabolism is deranged. A possible role of FGF19 in NAFLD has not been reported yet. In this study, we assessed intestinal FG...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2010-03, Vol.298 (3), p.G440-G445
Hauptverfasser:	Schreuder, Tim C M A, Marsman, Hendrik A, Lenicek, Martin, van Werven, Jochem R, Nederveen, Aart J, Jansen, Peter L M, Schaap, Frank G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Area Under Curve Bile Bile Acids and Salts - blood Bile Acids and Salts - metabolism Cholestenones - blood Cholestenones - metabolism Dietary Fats - metabolism Drug resistance Fatty Liver - blood Fatty Liver - metabolism Female Fibroblast Growth Factors - blood Fibroblast Growth Factors - metabolism Humans Insulin Insulin Resistance - physiology Intestines - metabolism Lipids Liver - metabolism Liver diseases Male Metabolism Middle Aged Patients Postprandial Period - physiology Triglycerides - blood Triglycerides - metabolism
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Beschreibung
Zusammenfassung:	Intestinal FGF19 has emerged as a novel endocrine regulator of hepatic bile salt and lipid metabolism. In patients with nonalcoholic fatty liver disease (NAFLD) hepatic lipid metabolism is deranged. A possible role of FGF19 in NAFLD has not been reported yet. In this study, we assessed intestinal FGF19 production and the hepatic response to FGF19 in NAFLD patients with and without insulin resistance [homeostasis model of assessment (HOMA) score > or =2.5 (n = 12) and HOMA score
ISSN:	0193-1857 1522-1547
DOI:	10.1152/ajpgi.00322.2009