Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System

FAAH inhibitors: This study identifies a new class of enol carbamates as potent, reversible inhibitors of fatty acid amide hydrolase (FAAH), endowed with high selectivity towards this target over other components of the endocannabinoid system.

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Veröffentlicht in:	ChemMedChem 2010-03, Vol.5 (3), p.357-360
Hauptverfasser:	Gattinoni, Sonia, De Simone, Chiara, Dallavalle, Sabrina, Fezza, Filomena, Nannei, Raffaella, Amadio, Daniele, Minetti, Patrizia, Quattrociocchi, Gianandrea, Caprioli, Antonio, Borsini, Franco, Cabri, Walter, Penco, Sergio, Merlini, Lucio, Maccarrone, Mauro
Format:	Artikel
Sprache:	eng
Schlagworte:	Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Animals Cannabinoid Receptor Modulators - metabolism Carbamates - administration & dosage Carbamates - chemistry Carbamates - metabolism Carbamates - pharmacology Endocannabinoids enol carbamates FAAH Humans hydrolases inhibitors Mice Plasma - metabolism Rats Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	FAAH inhibitors: This study identifies a new class of enol carbamates as potent, reversible inhibitors of fatty acid amide hydrolase (FAAH), endowed with high selectivity towards this target over other components of the endocannabinoid system.
ISSN:	1860-7179 1860-7187
DOI:	10.1002/cmdc.200900472