Pediatric Dose Selection

Selection of a drug dose in pediatrics is generally based on no or incomplete pharmacokinetic data. Traditionally, allometric, or scaling, techniques have been used; however, they have inherent limitations and may not make optimal use of the drug‐specific clinical pharmacokinetic information that is...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2010-03, Vol.87 (3), p.270-271
Hauptverfasser:	Abernethy, D R, Burckart, G J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Child Dose-Response Relationship, Drug Drug Dosage Calculations Drug-Related Side Effects and Adverse Reactions Humans Pediatrics - methods Pediatrics - trends Pharmaceutical Preparations - administration & dosage
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Beschreibung
Zusammenfassung:	Selection of a drug dose in pediatrics is generally based on no or incomplete pharmacokinetic data. Traditionally, allometric, or scaling, techniques have been used; however, they have inherent limitations and may not make optimal use of the drug‐specific clinical pharmacokinetic information that is available. Modeling is a tool that holds promise. The future challenge is to create a structured approach to determining pediatric doses for new therapeutic agents. Clinical Pharmacology & Therapeutics (2010) 87 3, 270–271. doi:10.1038/clpt.2009.292
ISSN:	0009-9236 1532-6535
DOI:	10.1038/clpt.2009.292