Advantageous Use of tBu2P-N=P(iBuNCH2CH2)3N in the Hiyama Coupling of Aryl Bromides and Chlorides

Advantageous Use of tBu2P-N=P(iBuNCH2CH2)3N in the Hiyama Coupling of Aryl Bromides and Chlorides

An efficient catalytic route to biaryls by employing (generally) only 0.25 mol % of Pd(OAc)(2) and 0.5 mol % of 1 in the Hiyama coupling reaction is reported. High yields for electron-rich, -neutral, and -deficient aryl chlorides are obtained. A variety of phenylsiloxanes undergo coupling with aryl...

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Veröffentlicht in:Journal of organic chemistry 2010-03, Vol.75 (5), p.1744-1747
Hauptverfasser: RADERS, Steven M, KINGSTON, Jesudoss V, VERKADE, John G
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Exact sciences and technology
Noncondensed benzenic compounds
Organic chemistry
Preparations and properties
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Zusammenfassung:An efficient catalytic route to biaryls by employing (generally) only 0.25 mol % of Pd(OAc)(2) and 0.5 mol % of 1 in the Hiyama coupling reaction is reported. High yields for electron-rich, -neutral, and -deficient aryl chlorides are obtained. A variety of phenylsiloxanes undergo coupling with aryl bromides and chlorides with low Pd(OAc)(2)/1 loadings.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo902338w