Molecular analysis of human immunoglobulin Vλ germline genes: Subgroups VλIII and VλIV
Three human immunoglobulin Vλ germline genes have been isolated: two from the VλIV subgroup and one from the VλIII subgroup. The VλIII gene and one of the VλIV genes appear to be functional (each being utilized in at least two expressed Vλ genes), despite deviations from the reported consensus seque...
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| Veröffentlicht in: | Molecular immunology 1992-12, Vol.29 (12), p.1515-1518 |
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| container_issue | 12 |
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| container_title | Molecular immunology |
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| creator | Daley, M.Denise Hong-qi, Peng Misener, Virginia Xiao-Yuan, Liu Chen, Pojen P. Siminovitch, Katherine A. |
| description | Three human immunoglobulin Vλ germline genes have been isolated: two from the VλIV subgroup and one from the VλIII subgroup. The VλIII gene and one of the VλIV genes appear to be functional (each being utilized in at least two expressed Vλ genes), despite deviations from the reported consensus sequences in their promoter TATA-box and recombination signal sequence elements. The other VλIV gene is a pseudogene. Of the 20 human Vλ germline genes characterized to date, 45% are pseudogenes or vestigial genes. |
| doi_str_mv | 10.1016/0161-5890(92)90226-N |
| format | Article |
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The VλIII gene and one of the VλIV genes appear to be functional (each being utilized in at least two expressed Vλ genes), despite deviations from the reported consensus sequences in their promoter TATA-box and recombination signal sequence elements. The other VλIV gene is a pseudogene. Of the 20 human Vλ germline genes characterized to date, 45% are pseudogenes or vestigial genes.</description><identifier>ISSN: 0161-5890</identifier><identifier>EISSN: 1872-9142</identifier><identifier>DOI: 10.1016/0161-5890(92)90226-N</identifier><identifier>PMID: 1454067</identifier><identifier>CODEN: MOIMD5</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Amino Acid Sequence ; Base Sequence ; Biological and medical sciences ; Cloning, Molecular ; Fundamental and applied biological sciences. Psychology ; Gene Library ; Genes, Immunoglobulin ; Genes. 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The VλIII gene and one of the VλIV genes appear to be functional (each being utilized in at least two expressed Vλ genes), despite deviations from the reported consensus sequences in their promoter TATA-box and recombination signal sequence elements. The other VλIV gene is a pseudogene. Of the 20 human Vλ germline genes characterized to date, 45% are pseudogenes or vestigial genes.</description><subject>Amino Acid Sequence</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Cloning, Molecular</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Library</subject><subject>Genes, Immunoglobulin</subject><subject>Genes. Genome</subject><subject>Humans</subject><subject>Immunoglobulin lambda-Chains - genetics</subject><subject>Immunoglobulin Variable Region - genetics</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><subject>Molecular Sequence Data</subject><subject>Pseudogenes</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sequence Homology, Nucleic Acid</subject><subject>TATA Box</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM2KFDEUhYM4jO3oGyjUQkQXpfmrVMWFIIM6DeO4UAdchSR100ZSlTbpCPNs8w4-k6npZtyNi9wcOOceLh9CTwh-RTARr-sjbTdI_ELSlxJTKtqLe2hFhp62knB6H61uIw_Qw5x_YowFFt0xOia841j0K_T9UwxgS9Cp0bMOV9nnJrrmR5n03PhpKnPchGhK8HNz-ee62UCaqoYqZshvmi_FbFIs27y46_W6tow38vIROnI6ZHh8-E_Qtw_vv56eteefP65P3523lpN-19ahe2wMI720PWYcDB_ZMAyj4yANswOTznEhmRw7J4zuqDWYu45ZYqjA7AQ93_duU_xVIO_U5LOFEPQMsWTVMyYGwdh_g0TwgREsapDvgzbFnBM4tU1-0ulKEawW9GrhqhauSlJ1g15d1LWnh_5iJhj_Le1ZV__ZwdfZ6uCSnq3PtzHOsaT9cubbfQwqtN8eksrWw2xh9AnsTo3R333HXwAjoQk</recordid><startdate>19921201</startdate><enddate>19921201</enddate><creator>Daley, M.Denise</creator><creator>Hong-qi, Peng</creator><creator>Misener, Virginia</creator><creator>Xiao-Yuan, Liu</creator><creator>Chen, Pojen P.</creator><creator>Siminovitch, Katherine A.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19921201</creationdate><title>Molecular analysis of human immunoglobulin Vλ germline genes: Subgroups VλIII and VλIV</title><author>Daley, M.Denise ; Hong-qi, Peng ; Misener, Virginia ; Xiao-Yuan, Liu ; Chen, Pojen P. ; Siminovitch, Katherine A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-417a70bb3179c7034eb4d3888df4e9b3c839ff46939d5f6ba52cb04f53c1b2603</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Amino Acid Sequence</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Cloning, Molecular</topic><topic>Fundamental and applied biological sciences. 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Genome</topic><topic>Humans</topic><topic>Immunoglobulin lambda-Chains - genetics</topic><topic>Immunoglobulin Variable Region - genetics</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><topic>Molecular Sequence Data</topic><topic>Pseudogenes</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>TATA Box</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Daley, M.Denise</creatorcontrib><creatorcontrib>Hong-qi, Peng</creatorcontrib><creatorcontrib>Misener, Virginia</creatorcontrib><creatorcontrib>Xiao-Yuan, Liu</creatorcontrib><creatorcontrib>Chen, Pojen P.</creatorcontrib><creatorcontrib>Siminovitch, Katherine A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Daley, M.Denise</au><au>Hong-qi, Peng</au><au>Misener, Virginia</au><au>Xiao-Yuan, Liu</au><au>Chen, Pojen P.</au><au>Siminovitch, Katherine A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular analysis of human immunoglobulin Vλ germline genes: Subgroups VλIII and VλIV</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>1992-12-01</date><risdate>1992</risdate><volume>29</volume><issue>12</issue><spage>1515</spage><epage>1518</epage><pages>1515-1518</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><coden>MOIMD5</coden><abstract>Three human immunoglobulin Vλ germline genes have been isolated: two from the VλIV subgroup and one from the VλIII subgroup. The VλIII gene and one of the VλIV genes appear to be functional (each being utilized in at least two expressed Vλ genes), despite deviations from the reported consensus sequences in their promoter TATA-box and recombination signal sequence elements. The other VλIV gene is a pseudogene. Of the 20 human Vλ germline genes characterized to date, 45% are pseudogenes or vestigial genes.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1454067</pmid><doi>10.1016/0161-5890(92)90226-N</doi><tpages>4</tpages></addata></record> |
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| ispartof | Molecular immunology, 1992-12, Vol.29 (12), p.1515-1518 |
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| subjects | Amino Acid Sequence Base Sequence Biological and medical sciences Cloning, Molecular Fundamental and applied biological sciences. Psychology Gene Library Genes, Immunoglobulin Genes. Genome Humans Immunoglobulin lambda-Chains - genetics Immunoglobulin Variable Region - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Pseudogenes Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid TATA Box |
| title | Molecular analysis of human immunoglobulin Vλ germline genes: Subgroups VλIII and VλIV |
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