Molecular analysis of human immunoglobulin Vλ germline genes: Subgroups VλIII and VλIV

Three human immunoglobulin Vλ germline genes have been isolated: two from the VλIV subgroup and one from the VλIII subgroup. The VλIII gene and one of the VλIV genes appear to be functional (each being utilized in at least two expressed Vλ genes), despite deviations from the reported consensus seque...

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Veröffentlicht in:	Molecular immunology 1992-12, Vol.29 (12), p.1515-1518
Hauptverfasser:	Daley, M.Denise, Hong-qi, Peng, Misener, Virginia, Xiao-Yuan, Liu, Chen, Pojen P., Siminovitch, Katherine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Biological and medical sciences Cloning, Molecular Fundamental and applied biological sciences. Psychology Gene Library Genes, Immunoglobulin Genes. Genome Humans Immunoglobulin lambda-Chains - genetics Immunoglobulin Variable Region - genetics Molecular and cellular biology Molecular genetics Molecular Sequence Data Pseudogenes Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid TATA Box
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Zusammenfassung:	Three human immunoglobulin Vλ germline genes have been isolated: two from the VλIV subgroup and one from the VλIII subgroup. The VλIII gene and one of the VλIV genes appear to be functional (each being utilized in at least two expressed Vλ genes), despite deviations from the reported consensus sequences in their promoter TATA-box and recombination signal sequence elements. The other VλIV gene is a pseudogene. Of the 20 human Vλ germline genes characterized to date, 45% are pseudogenes or vestigial genes.
ISSN:	0161-5890 1872-9142
DOI:	10.1016/0161-5890(92)90226-N