Comparative Effects of Benidipine and Amlodipine on Proteinuria, Urinary 8-OHdG, Urinary L-FABP, and Inflammatory and Atherosclerosis Markers in Early-Stage Chronic Kidney Disease

We examined the effects of 2 calcium channel blockers, benidipine (T-, L-, and N-type) and amlodipine (L- and N-type), on renal, inflammatory, oxidative, and atherosclerosis markers in hypertensive patients with mild chronic kidney disease (CKD). Forty hypertensive patients with CKD were assigned randomly to either of the 2 treatments: 8mg benidipine once daily (n=20, group A) or 5mg amlodipine once daily (n=20, group B). Treatment was continued for 12months. Blood pressure, serum creatinine, estimated glomerular filtration rate, urinary protein excretion, urinary liver-type fatty acid-binding protein, interleukin-6, high mobility group box-1 protein, urinary 8-hydroxy-2′- deoxyguanosine, pulse wave velocity, intima-media thickness, and blood asymmetric dimethylarginine were monitored. Blood pressure decreased equally in both groups (P