Rossinones A and B, Biologically Active Meroterpenoids from the Antarctic Ascidian, Aplidium species

Rossinones A (1) and B (2), biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species and structurally characterized with spectroscopic methods. The absolute configuration of 1 was deduced by using the modified Mosher method. The rossino...

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Veröffentlicht in:	Journal of organic chemistry 2009-12, Vol.74 (23), p.9195-9198
Hauptverfasser:	Appleton, David R, Chuen, Cheah Shiau, Berridge, Michael V, Webb, Victoria L, Copp, Brent R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alicyclic compounds, terpenoids, prostaglandins, steroids Animals Antarctic Regions Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antiviral Agents - chemistry Antiviral Agents - isolation & purification Biological and medical sciences Chemistry Exact sciences and technology Medical sciences Molecular Structure Organic chemistry Pharmacology. Drug treatments Preparations and properties Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology Terpenoids Urochordata - chemistry
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Beschreibung
Zusammenfassung:	Rossinones A (1) and B (2), biologically active meroterpene derivatives, were isolated from an Antarctic collection of the ascidian Aplidium species and structurally characterized with spectroscopic methods. The absolute configuration of 1 was deduced by using the modified Mosher method. The rossinones exhibit anti-inflammatory, antiviral and antiproliferative activities.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo901846j