Lin28: A MicroRNA Regulator with a Macro Role

Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.

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Bibliographische Detailangaben
Veröffentlicht in:	Cell 2010-02, Vol.140 (4), p.445-449
Hauptverfasser:	Viswanathan, Srinivas R., Daley, George Q.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Humans Induced Pluripotent Stem Cells - metabolism MicroRNAs - genetics Neoplasms - metabolism Protein Processing, Post-Translational RNA-Binding Proteins - genetics Stem Cells - metabolism
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.
ISSN:	0092-8674 1097-4172
DOI:	10.1016/j.cell.2010.02.007