Early Changes in the Biophysical Properties of the Aorta in Pre-Adolescent Children Born Small for Gestational Age

Early Changes in the Biophysical Properties of the Aorta in Pre-Adolescent Children Born Small for Gestational Age

Objective To assess the biophysical properties of the aorta in children born small for gestational age (SGA) with an echo-Doppler method and to determine associations with known perinatal risk factors. Study design In this cross-sectional study, 39 SGA and 41 control subjects aged 8 to 13 years were...

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Veröffentlicht in:The Journal of pediatrics 2010-03, Vol.156 (3), p.388-392
Hauptverfasser: Bradley, Timothy J., MB, ChB, Potts, James E., PhD, Lee, Shoo K., MBBS, PhD, Potts, Mary T., RDMS, De Souza, Astrid M., MSc, Sandor, George G.S., MB, ChB
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Aorta, Thoracic - diagnostic imaging
Aorta, Thoracic - physiology
Biological and medical sciences
Biomechanical Phenomena
Blood Flow Velocity
Blood Pressure
Body Mass Index
Cardiovascular Diseases - diagnosis
Child
Diseases of mother, fetus and pregnancy
Echocardiography, Doppler
Elasticity
Female
Follow-Up Studies
General aspects
Gynecology. Andrology. Obstetrics
Heart Rate
Humans
Infant, Newborn
Infant, Small for Gestational Age
Male
Medical sciences
Pediatrics
Pregnancy. Fetus. Placenta
Risk Factors
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Zusammenfassung:Objective To assess the biophysical properties of the aorta in children born small for gestational age (SGA) with an echo-Doppler method and to determine associations with known perinatal risk factors. Study design In this cross-sectional study, 39 SGA and 41 control subjects aged 8 to 13 years were recruited. Perinatal risk factors were recorded. The aortic diameters and pulse wave transit time around the aortic arch were measured with echo-Doppler and the blood pressure recorded. Pulse wave velocity, aortic input impedance (Zi), characteristic impedance (Zc), arterial pressure-strain elastic modulus (Ep), and arterial wall stiffness index (β-index) were calculated. Results Pulse wave velocity (374 ± 46 vs 348 ± 47cm/sec, P < .02); Zi (177 ± 39 vs 142 ± 27 dynes · sec/cm5 , P  
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2009.10.002