Effect of low dose Amiodarone on the incidence of sudden death in elderly patients with congestive heart failure: A double-bind, placebo-controlled study
To determine if low-dose Amiodarone could reduce sudden death (SD) among patients with congestive heart failure, a prospective, double-blind, placebo-controlled study was conducted. The study group consisted of 46 patients (36 men and 10 women, mean age 71 ± 5 years) with complex ventricular ectopy...
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Veröffentlicht in: | Archives of gerontology and geriatrics 1996, Vol.22, p.191-195 |
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Sprache: | eng |
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Zusammenfassung: | To determine if low-dose Amiodarone could reduce sudden death (SD) among patients with congestive heart failure, a prospective, double-blind, placebo-controlled study was conducted. The study group consisted of 46 patients (36 men and 10 women, mean age 71 ± 5 years) with complex ventricular ectopy documented by 48-hour Holter monitoring. Randomization divided the patients into two treatment groups: the first group received Amiodarone (400 mg/day for 1 week and then 100 mg/day), while the second group received placebo. The drug significantly reduced ventricular arrhythmias, but then was no decrease in incidence of SD. This study demonstrates not only that low-dose Amiodarone can be safely administered to elderly patients with congestive heart failure and it will significantly suppress ventricular arrhythmias, but also that reduction in ventricular arrhythmias and the risk of SD are not linearly related. |
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ISSN: | 0167-4943 1872-6976 |
DOI: | 10.1016/0167-4943(96)86934-2 |