Permeability of alginate microcapsules to secretory recombinant gene products

Permeability of alginate microcapsules to secretory recombinant gene products

Non‐autologous somatic gene therapy is an alternate approach to delivering recombinant gene products through implantation of a “universal” donor cell line engineered to produce a therapeutic gene product. The cells are immunologically isolated by enclosure in immunoprotective microcapsules fabricate...

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Veröffentlicht in:Biotechnology and bioengineering 1996-11, Vol.52 (4), p.472-484
Hauptverfasser: Awrey, D. E., Tse, M., Hortelano, G., Chang, P. L.
Format: Artikel
Sprache:eng
Schlagworte:
albumin
Biological and medical sciences
Biotechnology
Fundamental and applied biological sciences. Psychology
Gene therapy
growth hormone
Health. Pharmaceutical industry
immunoglobulin
Industrial applications and implications. Economical aspects
lysosomal enzymes
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Zusammenfassung:Non‐autologous somatic gene therapy is an alternate approach to delivering recombinant gene products through implantation of a “universal” donor cell line engineered to produce a therapeutic gene product. The cells are immunologically isolated by enclosure in immunoprotective microcapsules fabricated from alginate‐poly‐L‐lysine‐alginate. The molecular weight cutoff of these microcapsules was thought to be
ISSN:0006-3592
1097-0290
DOI:10.1002/(SICI)1097-0290(19961120)52:4<472::AID-BIT3>3.0.CO;2-M