L-DOPA improves visuo-motor coordination in stable Parkinson’s disease patients

The visuo-motor coordination of 26 stable, treated, Parkinson’s disease (PD) patients with average Hoehn and Yahr rating of 1.75±0.6, was assessed by use of several tracing and tracking tests before and 30 min after ingestion of the mid-day levodopa (L-DOPA) dose. Significant improvement was found i...

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Veröffentlicht in:Parkinsonism & related disorders 1998-10, Vol.4 (3), p.129-136
Hauptverfasser: Hocherman, S., Alexandrovsky, L., Badarny, S., Honigman, S.
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Sprache:eng
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Zusammenfassung:The visuo-motor coordination of 26 stable, treated, Parkinson’s disease (PD) patients with average Hoehn and Yahr rating of 1.75±0.6, was assessed by use of several tracing and tracking tests before and 30 min after ingestion of the mid-day levodopa (L-DOPA) dose. Significant improvement was found in all aspects of visuo-motor coordination 30 min after drug intake. This included the ability to control the direction and velocity of hand-movement, and the capacity to persist in tracking. A subgroup of 12 patients was tested 30 min and 1 h after L-DOPA intake. A continuing (but small) improvement in directional and velocity control could still be seen an hour after drug intake, while tracking persistence remained unchanged with respect to the preceding test. We conclude that changes in executional capabilities can be documented in “stable” PD patients, consequent to L-DOPA intake, when high-level skills, such as visuo-motor coordination, are tested.
ISSN:1353-8020
1873-5126
DOI:10.1016/S1353-8020(98)00034-0