Glycodelin-A modulates cytokine production of peripheral blood natural killer cells

Glycodelin-A modulates cytokine production of peripheral blood natural killer cells

Glycodelin-A increased the secretion of interleukin-6, interleukin-13, and granulocyte-macrophage colony-stimulating factor from natural killer cells in the peripheral blood but does not affect their viability, cell death, and cytotoxicity. These data suggest that glycodelin-A contributes to the cyt...

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Veröffentlicht in:Fertility and sterility 2010-07, Vol.94 (2), p.769-771
Hauptverfasser: Lee, Cheuk-Lun, Ph.D, Chiu, Philip C.N., Ph.D, Lam, Kevin K.W., B.Sc, Chan, Rachel W.S., Ph.D, Chu, Ivan K., Ph.D, Koistinen, Riitta, Ph.D, Koistinen, Hannu, D.Sc, Seppälä, Markku, M.D., Ph.D, Lee, Kai-Fai, Ph.D, Yeung, William S.B., Ph.D
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
Cell Death - immunology
Cell Survival - immunology
Cytokines - immunology
Cytokines - metabolism
Decidua - cytology
Decidua - immunology
Decidua - metabolism
Female
Glycodelin
Glycoproteins - immunology
Glycoproteins - metabolism
Glycoproteins - pharmacology
Granulocyte-Macrophage Colony-Stimulating Factor - immunology
Granulocyte-Macrophage Colony-Stimulating Factor - metabolism
Gynecology. Andrology. Obstetrics
Humans
In Vitro Techniques
Interleukin-13 - immunology
Interleukin-13 - metabolism
Interleukin-6 - immunology
Interleukin-6 - metabolism
Internal Medicine
Killer Cells, Natural - cytology
Killer Cells, Natural - drug effects
Killer Cells, Natural - immunology
Medical sciences
Obstetrics and Gynecology
Pregnancy
Pregnancy Proteins - immunology
Pregnancy Proteins - metabolism
Pregnancy Proteins - pharmacology
Pregnancy Trimester, First - immunology
Pregnancy Trimester, First - metabolism
Trophoblasts - cytology
Trophoblasts - immunology
Trophoblasts - metabolism
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Zusammenfassung:Glycodelin-A increased the secretion of interleukin-6, interleukin-13, and granulocyte-macrophage colony-stimulating factor from natural killer cells in the peripheral blood but does not affect their viability, cell death, and cytotoxicity. These data suggest that glycodelin-A contributes to the cytokine shift in early pregnancy.
ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2009.10.009