Determination of absolute configuration of trimeric indole alkaloid, psychotrimine, by first asymmetric total synthesis

The first asymmetric total synthesis of psychotrimine, a trimeric indole alkaloid, was accomplished via an asymmetric Ireland-Claisen rearrangement to construct a chiral quaternary carbon center, thereby establishing the absolute configuration of psychotrimine.

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Bibliographische Detailangaben
Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2010-01, Vol.46 (14), p.2501-2503
Hauptverfasser:	Takahashi, Nobuaki, Ito, Takeshi, Matsuda, Yohei, Kogure, Noriyuki, Kitajima, Mariko, Takayama, Hiromitsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Carbon - chemistry Cell Line, Tumor Drug Screening Assays, Antitumor Humans Indole Alkaloids - chemical synthesis Indole Alkaloids - chemistry Indole Alkaloids - toxicity Molecular Conformation
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Beschreibung
Zusammenfassung:	The first asymmetric total synthesis of psychotrimine, a trimeric indole alkaloid, was accomplished via an asymmetric Ireland-Claisen rearrangement to construct a chiral quaternary carbon center, thereby establishing the absolute configuration of psychotrimine.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b923918a