Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine

Combining the first generation H(1) antihistamine chlorpheniramine (1) with H(3) ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H(1) and H(3) receptors.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2003-06, Vol.13 (12), p.1959-1961
Hauptverfasser:	ASLANIAN, Robert, MUTAHI, Mwangi Wa, SHIH, Neng-Yang, PIWINSKI, John J, WEST, Robert, WILLIAMS, Shirley M, SHE, Susan, WU, Ren-Long, HEY, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chlorpheniramine - analogs & derivatives Chlorpheniramine - metabolism Chlorpheniramine - pharmacology Guinea Pigs Histamine Antagonists - chemistry Histamine Antagonists - metabolism Histamine Antagonists - pharmacology Histamine H1 Antagonists - chemistry Histamine H1 Antagonists - metabolism Histamine H1 Antagonists - pharmacology Ligands Medical sciences Miscellaneous Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Receptors, Histamine H1 - metabolism Receptors, Histamine H3 - metabolism Structure-Activity Relationship
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Beschreibung
Zusammenfassung:	Combining the first generation H(1) antihistamine chlorpheniramine (1) with H(3) ligands of the alkylamine type has led to the identification of compound 9d, a dual ligand of both the H(1) and H(3) receptors.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/s0960-894x(03)00357-3