Multi-tasking with Single Platform Dendrimers for Targeting Sub-Cellular Microenvironments

Double trouble! Orthogonally functionalised dendrimers have been constructed by using a versatile approach that is widely applicable for therapeutics and diagnostics by combining imaging agents and therapeutics for synergistic effects. Dendrimers containing a covalently linked dipyrromethene boron d...

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Veröffentlicht in:	Chemistry : a European journal 2010-06, Vol.16 (21), p.6164-6168
Hauptverfasser:	Hourani, Rami, Jain, Manasi, Maysinger, Dusica, Kakkar, Ashok
Format:	Artikel
Sprache:	eng
Schlagworte:	biological activity Boron Compounds - chemistry Cell Line, Tumor Chemical compounds Chemistry click chemistry Covalence Dendrimers Dendrimers - chemistry Dendrimers - toxicity Diagnostic systems Droplets Humans Lipids Microscopy, Confocal multiple functionalities Pharmacology Platforms Thioctic Acid - chemistry
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Beschreibung
Zusammenfassung:	Double trouble! Orthogonally functionalised dendrimers have been constructed by using a versatile approach that is widely applicable for therapeutics and diagnostics by combining imaging agents and therapeutics for synergistic effects. Dendrimers containing a covalently linked dipyrromethene boron difluoride (BODIPY) dye and α‐lipoic acid perform complementary biological functions and target intracellular lipid droplets (see figure).
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.201000241