Patlak plot analysis CT-GFR for the determination of renal function: comparison of normal dogs with autologous kidney transplant dogs

Glomerular filtration rate (GFR) can be determined using Patlak plot analysis with single‐slice dynamic computed tomography (CT). Acute autologous graft failure has several causes, all of which induce a measurable decrease in glomerular filtration rate. This study demonstrated in an experimental model of canine autologous renal transplant that CT‐derived renal plasma clearance was significantly lower (p = 0.002) in dogs having undergone transplant (0.077 ± 0.058 ml min−1 ml renal tissue−1) compared with control dogs (0.396 ± 0.139 ml min−1 ml renal tissue−1). A significant negative curvilinear relationship was seen between serum creatinine and total renal plasma clearance (R2 = 0.84, p = 0.0001). Alterations in renal time attenuation curve shape in dogs having undergone transplant may have been related to increased renal vascular resistance related to tubular necrosis. CT‐GFR may be a useful experimental tool in the evaluation of renal dysfunction in transplant models. Copyright © 2010 John Wiley & Sons, Ltd. CT‐derived renal plasma clearance was significantly lower in dogs having undergone autologous renal transplant and a relationship was seen between serum creatinine and total renal plasma clearance. CT‐GFR appears useful in evaluating renal transplant models.