Antimicrobial, Hemolytic, and Cytotoxic Activities of β-Peptoid-Peptide Hybrid Oligomers: Improved Properties Compared to Natural AMPs

β‐Peptoid–peptide hybrid oligomers prepared by efficient Fmoc solid‐phase synthesis by using dimeric building blocks were shown to possess antimicrobial activities towards a range of pathogens. Low mammalian cell toxicity and extremely high stability towards enzymatic degradation were additional favorable properties. Notably, lead compounds against P. aeruginosa and C. albicans were discovered, and potent candidates against E. coli, vancomycin‐resistant enterococci, and methicillin‐resistant S. aureus were also identified.