Hematopoietic stem and progenitor cells in HIV/AIDS and immune reconstitution

The human immunodeficiency virus type 1 （HIV-1） causes an acquired immunodeficiency syndrome （AIDS）. HIV-1 infects human immune cells, specifically CD4＋ lymphocytes, which leads to AIDS and undermines reconstitution of immunity. The unique challenges of HIV/AIDS have triggered multidisciplinary inve...

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Veröffentlicht in:	Cell research 2010-07, Vol.20 (7), p.745-747
Hauptverfasser:	Zhang, Jielin, Crumpacker, Clyde S
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/255/1901 631/532/1542 Antigens, CD34 - immunology Biomedical and Life Sciences Cell Biology Hematopoietic Stem Cells - virology HIV HIV - growth & development HIV - isolation & purification HIV Infections - immunology Humans Life Sciences Multipotent Stem Cells - virology research-highlight T淋巴细胞 Virus Replication 人类免疫缺陷病毒免疫细胞细胞生物学细胞重建艾滋病毒造血干细胞
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Beschreibung
Zusammenfassung:	The human immunodeficiency virus type 1 （HIV-1） causes an acquired immunodeficiency syndrome （AIDS）. HIV-1 infects human immune cells, specifically CD4＋ lymphocytes, which leads to AIDS and undermines reconstitution of immunity. The unique challenges of HIV/AIDS have triggered multidisciplinary investigators to study the virology of the pathogen and the biology of the host cells, especially the interactions of HIV- 1 with T-lymphocytes, macrophages, and hematopoietic stem and progenitor cells （HSPC） [1-8].
ISSN:	1001-0602 1748-7838
DOI:	10.1038/cr.2010.85