One-pot cross-coupling of N-acyl N,O-acetals with alpha,beta-unsaturated compounds

One-pot cross-coupling of N-acyl N,O-acetals with alpha,beta-unsaturated compounds

The synergistic action of BF(3).OEt(2) and SmI(2) allowed a series of intermolecular cross-couplings of readily available N-acyl N,O-acetals with alpha,beta-unsaturated compounds to be performed in high yields, which was applied to the stereoselective synthesis of pyrrolizidine alkaloid (+)-xenoveni...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2009-01 (45), p.7045-7047
Hauptverfasser: Xiang, Yong-Gang, Wang, Xiang-Wu, Zheng, Xiao, Ruan, Yuan-Ping, Huang, Pei-Qiang
Format: Artikel
Sprache:eng
Schlagworte:
Acetals - chemical synthesis
Acetals - chemistry
Boranes - chemistry
Iodides - chemistry
Pyrrolizidine Alkaloids - chemical synthesis
Pyrrolizidine Alkaloids - chemistry
Samarium - chemistry
Stereoisomerism
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Zusammenfassung:The synergistic action of BF(3).OEt(2) and SmI(2) allowed a series of intermolecular cross-couplings of readily available N-acyl N,O-acetals with alpha,beta-unsaturated compounds to be performed in high yields, which was applied to the stereoselective synthesis of pyrrolizidine alkaloid (+)-xenovenine.
ISSN:1359-7345
1364-548X
DOI:10.1039/b915488d