The Constituents and Their Bioactivities of Houttuynia cordata

Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In t...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2009/11/01, Vol.57(11), pp.1227-1230
Hauptverfasser:	Chou, Shu-Chen, Su, Chung-Ren, Ku, Yuh-Chi, Wu, Tian-Shung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant Antioxidants - chemistry Antioxidants - isolation & purification Antioxidants - pharmacology antityrosinase Antiviral Agents - chemistry Antiviral Agents - isolation & purification Antiviral Agents - pharmacology Benzamides - chemistry Benzamides - isolation & purification Benzamides - pharmacology Benzoates - chemistry Benzoates - isolation & purification Benzoates - pharmacology Cercopithecus aethiops Dose-Response Relationship, Drug Enzyme Inhibitors - chemistry Enzyme Inhibitors - isolation & purification Enzyme Inhibitors - pharmacology Euphorbiaceae Glucosides - chemistry Glucosides - isolation & purification Glucosides - pharmacology Herpes simplex virus 1 herpes simplex virus type 1 Herpesvirus 1, Human - drug effects Houttuynia - chemistry Isoquinolines - chemistry Isoquinolines - isolation & purification Isoquinolines - pharmacology Microbial Sensitivity Tests Monophenol Monooxygenase - antagonists & inhibitors Plants, Medicinal - chemistry Quercetin - analogs & derivatives Quercetin - chemistry Quercetin - isolation & purification Quercetin - pharmacology Structure-Activity Relationship Vero Cells
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Zusammenfassung:	Chemical investigation on the whole plant of Houttuynia cordata has resulted in the isolation of two new compounds, named as houttuynoside A (1) and houttuynamide A (2), together with thirty-eight known compounds. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. In the inhibitory effects on herpes simplex virus type 1 (HSV-1) assay, norcepharadione B (10) showed good inhibitory activity against the replication of HSV-1. In addition, the antioxidant and antityrosinase activities of some isolated compounds were also evaluated. Among these compounds, quercitrin (25) and quercetin-3-O-β-D-galactopyranoside (26) showed excellent 2,2-diphenyl-1-picrylhydrazyl radical-scavenging property with IC50 values of 31 and 63 μM, respectively. Cepharadione B (9) exhibited strong tyrosinase inhibitory activity with an IC50 value of 170 μM.
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.57.1227