Cytogenetic findings in a case of dedifferentiated chondrosarcoma

Cytogenetic findings in a case of dedifferentiated chondrosarcoma

Cytogenetic analysis of a case of dedifferentiated chondrosarcoma with a malignant fibrous histiocytoma (MFH) component revealed a near-triploid karyotype with multiple copies of chromosome 7, deletion of chromosome arm 9p, and a derivative chromosome 19 [add(19p)] in each metaphase. Whereas numeric...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancer genetics and cytogenetics 2003-07, Vol.144 (1), p.61-64
Hauptverfasser: Casorzo, Laura, Chiecchio, Laura, Pisacane, Alberto, Fumero, Sergio, Canavese, Federico, Torchio, Bruno, Risio, Mauro
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Biological and medical sciences
Cell Differentiation
Chondrosarcoma - genetics
Chondrosarcoma - pathology
Diseases of the osteoarticular system
Female
Humans
Karyotyping
Loss of Heterozygosity
Medical sciences
Tumors of striated muscle and skeleton
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cytogenetic analysis of a case of dedifferentiated chondrosarcoma with a malignant fibrous histiocytoma (MFH) component revealed a near-triploid karyotype with multiple copies of chromosome 7, deletion of chromosome arm 9p, and a derivative chromosome 19 [add(19p)] in each metaphase. Whereas numerical anomalies of chromosome 7 have been frequently reported in chondrosarcoma, deletion 9p and add (19p) have been observed in MFH. A putative MFH tumor suppressor gene could be present in a critical region on chromosome bands 9p21~p22.
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(02)00866-X