Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder

Neuregulin (NRG) 1Iα and NRG3 proteins levels were measured in Brodmann's area 46 from 20 subjects with schizophrenia, 8 subjects with bipolar 1 disorder and 20 age-sex matched control subjects. Protein levels of both NRG1Iα and NRG3 were unchanged in both psychiatric illnesses. These data sugg...

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Veröffentlicht in:	Neuroscience letters 2009-11, Vol.466 (1), p.27-29
Hauptverfasser:	Boer, Simone, Berk, Michael, Dean, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Biological and medical sciences Bipolar disorder Bipolar Disorder - metabolism Fundamental and applied biological sciences. Psychology Humans Medical sciences Neuregulin Neuregulin-1 - genetics Neuregulin-1 - metabolism Neuregulins - genetics Neuregulins - metabolism Prefrontal Cortex - metabolism Protein Isoforms Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - metabolism Vertebrates: nervous system and sense organs
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Zusammenfassung:	Neuregulin (NRG) 1Iα and NRG3 proteins levels were measured in Brodmann's area 46 from 20 subjects with schizophrenia, 8 subjects with bipolar 1 disorder and 20 age-sex matched control subjects. Protein levels of both NRG1Iα and NRG3 were unchanged in both psychiatric illnesses. These data suggest any change in NRG1Iα and NRG3 expression in schizophrenia or bipolar 1 disorder do not result in changes levels in levels of those proteins Brodmann's area 46.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/j.neulet.2009.09.019