Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins

Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins

Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides. Anti-HIV fusion inhibitory peptides with N- and C-termin...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2009-11, Vol.17 (21), p.7487-7492
Hauptverfasser: Tanaka, Michinori, Kajiwara, Kazumi, Tokiwa, Rei, Watanabe, Kentaro, Ohno, Hiroaki, Tsutsumi, Hiroko, Hata, Yoji, Izumi, Kazuki, Kodama, Eiichi, Matsuoka, Masao, Oishi, Shinya, Fujii, Nobutaka
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Anti-HIV Agents - chemical synthesis
Anti-HIV Agents - chemistry
Anti-HIV Agents - pharmacology
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Biological and medical sciences
Bioorganic synthesis
Cysteine - chemistry
End-capped peptide
Fusion inhibitor
HIV Fusion Inhibitors - chemical synthesis
HIV Fusion Inhibitors - chemistry
HIV Fusion Inhibitors - pharmacology
HIV-1
Human immunodeficiency virus
Humans
Medical sciences
Molecular Sequence Data
Peptides - chemical synthesis
Peptides - chemistry
Peptides - pharmacology
Pharmacology. Drug treatments
Recombinant Fusion Proteins - metabolism
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Zusammenfassung:Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides. Anti-HIV fusion inhibitory peptides with N- and C-terminal end-capping groups was synthesized by two simultaneous S-cyanocysteine-mediated cleavages of recombinant proteins.
ISSN:0968-0896
1464-3391
DOI:10.1016/j.bmc.2009.09.015