Clinical trial: gastric acid suppression in Hispanic adults with symptomatic gastro‐oesophageal reflux disease – comparator study of esomeprazole, lansoprazole and pantoprazole

Aliment Pharmacol Ther 2010; 32: 200–208 Summary Background  Hispanic‐Americans are a rapidly growing population in the United States, yet gastro‐oesophageal reflux disease (GERD) is not well studied in this population. Aim  To compare the efficacy of esomeprazole, lansoprazole and pantoprazole in s...

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Veröffentlicht in:Alimentary pharmacology & therapeutics 2010-07, Vol.32 (2), p.200-208
Hauptverfasser: Morgan, D., Pandolfino, J., Katz, P. O., Goldstein, J. L., Barker, P. N., Illueca, M.
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Sprache:eng
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Zusammenfassung:Aliment Pharmacol Ther 2010; 32: 200–208 Summary Background  Hispanic‐Americans are a rapidly growing population in the United States, yet gastro‐oesophageal reflux disease (GERD) is not well studied in this population. Aim  To compare the efficacy of esomeprazole, lansoprazole and pantoprazole in suppressing gastric acid, including the area of the ‘acid pocket,’ in Hispanics with GERD. Methods  In this open‐label, 3‐way crossover study, 83 Hispanics with symptomatic GERD were randomized to 1 of 6 possible treatment sequences of three 5–7‐day dosing periods with esomeprazole 40 mg, lansoprazole 30 mg and pantoprazole 40 mg daily separated by 10–17‐day washout periods. Intragastric pH was measured for 24 h using dual probes with a distal and proximal (area of the ‘acid pocket’) electrode. Results  Esomeprazole suppressed intragastric acid (pH >4.0) significantly longer over 24 h (primary end point) compared with lansoprazole and pantoprazole (P 4.0) significantly longer over 24 h compared with lansoprazole (P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2010.04335.x