First obtaining of glass solutions and phase diagram of glucose with fully tunable anomeric concentration

In this article we show the possibility to form amorphous α‐glucose/β‐glucose molecular alloys directly in the solid state by comilling crystalline α‐glucose and crystalline β‐glucose. Contrary to the usual melt quenching process, milling does not induce any mutarotation so that alloys can be obtained for the whole range of anomeric concentration. This offers the unique possibility to explore the phase diagram of this binary system which appears to be a eutectic mixture. The structural and thermodynamic investigations have been performed by powder X‐ray diffraction and differential scanning calorimetry. © 2009 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 99: 1476–1483, 2010