Telomere Replication: An Est Fest

The search for subunits of the telomerase enzyme has uncovered orthologs of the budding yeast Est1 protein in several species, including humans. Thus, positive regulation of telomerase by Est1 appears to be a widely utilized mechanism for maintaining telomere length homeostasis.

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Bibliographische Detailangaben
Veröffentlicht in:	Current biology 2003-05, Vol.13 (11), p.R439-R441
1. Verfasser:	Lundblad, Vicki
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Homeostasis - physiology Models, Biological Molecular Sequence Data Saccharomyces cerevisiae Proteins - metabolism Sequence Alignment Telomerase - metabolism Telomere - metabolism Telomere - physiology
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Beschreibung
Zusammenfassung:	The search for subunits of the telomerase enzyme has uncovered orthologs of the budding yeast Est1 protein in several species, including humans. Thus, positive regulation of telomerase by Est1 appears to be a widely utilized mechanism for maintaining telomere length homeostasis.
ISSN:	0960-9822 1879-0445
DOI:	10.1016/S0960-9822(03)00365-8