The occurrence of hyponatremia in SCLC and the influence on prognosis A retrospective study of 453 patients treated in a single institution in a 10-year period

Hyponatremia is often seen in SCLC, and is thought to be caused by the paraneoplastic syndrome SIADH. Variable results of the prognostic significance of low P-sodium (P-Na) have been reported. This study was performed to investigate the prognostic value of hyponatremia in SCLC. Data was obtained fro...

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Veröffentlicht in:	Lung cancer (Amsterdam, Netherlands) Netherlands), 2010-04, Vol.68 (1), p.111-114
Hauptverfasser:	HANSEN, Olfred, SØRENSEN, Peter, HANSEN, Karin Holmskov
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Antineoplastic Combined Chemotherapy Protocols - administration & dosage Biological and medical sciences Biomarkers, Tumor - analysis Carboplatin - administration & dosage Disease Progression Etoposide - administration & dosage Female Humans Hyponatremia Lung Neoplasms - diagnosis Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - pathology Lung Neoplasms - physiopathology Male Medical sciences Neoplasm Staging Plasma - chemistry Pneumology Prognosis Retrospective Studies Sex Factors Small Cell Lung Carcinoma - diagnosis Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - mortality Small Cell Lung Carcinoma - pathology Small Cell Lung Carcinoma - physiopathology Sodium - analysis Sodium - deficiency Survival Analysis Tumors Tumors of the respiratory system and mediastinum
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Zusammenfassung:	Hyponatremia is often seen in SCLC, and is thought to be caused by the paraneoplastic syndrome SIADH. Variable results of the prognostic significance of low P-sodium (P-Na) have been reported. This study was performed to investigate the prognostic value of hyponatremia in SCLC. Data was obtained from files from 453 patients diagnosed with SCLC and treated at Odense University Hospital from 1995 to 2005 in which data on P-sodium was available. The standard chemotherapy was six cycles of carboplatin-etoposide. P-Na was
ISSN:	0169-5002 1872-8332
DOI:	10.1016/j.lungcan.2009.05.015