Amyloid goiter secondary to Crohn's disease

Secondary amyloidosis is generally caused by malignant tumors or chronic inflammatory diseases. Most cases of secondary amyloidosis are discovered due to proteinuria or nephrotic syndrome caused by renal amyloidosis. Clinically significant thyroid involvement is found in only a small percentage of cases, although a finding of amyloid deposit in autopsies is not infrequent. We present a case of amyloid goiter. The patient was diagnosed with Crohn's disease 7 years previously and had kidney failure of unknown cause. She was referred to our department for a goiter discovered incidentally. The patient finally underwent thyroidectomy due to progressive growth of the thyroid gland with compressive symptoms. The histologic analysis showed thyroid amyloidosis.