New reduction pathways for ctc-[PtCl2(CH3CO2)2(NH3)(Am)] anticancer prodrugs

Reduction of anticancer prodrugs such as ctc-[PtCl(2)(CH(3)CO(2))(2)(NH(3))(Am)] can yield three products in addition to the expected cis-[PtCl(2)(NH(3))(Am)]. A possible explanation is that reduction proceeds by several pathways where in addition to the loss of two axial ligands, one axial (acetato...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2010-03, Vol.46 (11), p.1842-1844
Hauptverfasser:	Nemirovski, Alina, Vinograd, Inbal, Takrouri, Khuloud, Mijovilovich, Ana, Rompel, Annette, Gibson, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Organoplatinum Compounds - chemistry Oxidation-Reduction Prodrugs - chemistry Prodrugs - pharmacology X-Ray Absorption Spectroscopy
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Beschreibung
Zusammenfassung:	Reduction of anticancer prodrugs such as ctc-[PtCl(2)(CH(3)CO(2))(2)(NH(3))(Am)] can yield three products in addition to the expected cis-[PtCl(2)(NH(3))(Am)]. A possible explanation is that reduction proceeds by several pathways where in addition to the loss of two axial ligands, one axial (acetato) and one equatorial (chlorido) ligand, or two equatorial ligands are eliminated.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/b925721g