Total Synthesis of Pteridic Acids A and B

The total synthesis of pteridic acids A and B is reported. The convergent asymmetric synthesis involved the use of a diastereoselective ethyl ketone aldol reaction followed by an efficient spiroketalization and provided pteridic acids A and B in 2.9% and 2.8% overall yield, respectively.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of organic chemistry 2009-08, Vol.74 (15), p.5584-5589
Hauptverfasser:	Dias, Luiz C, Salles, Airton G
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heptanoic Acids - chemical synthesis Heptanoic Acids - chemistry Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Molecular Conformation Organic chemistry Preparations and properties Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Stereoisomerism
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Beschreibung
Zusammenfassung:	The total synthesis of pteridic acids A and B is reported. The convergent asymmetric synthesis involved the use of a diastereoselective ethyl ketone aldol reaction followed by an efficient spiroketalization and provided pteridic acids A and B in 2.9% and 2.8% overall yield, respectively.
ISSN:	0022-3263 1520-6904
DOI:	10.1021/jo9010365