A Haplotype of the Norepinephrine Transporter (Net) Gene Slc6a2 is Associated with Clinical Response to Atomoxetine in Attention-Deficit Hyperactivity Disorder (ADHD)

Atomoxetine is a specific inhibitor of the norepinephrine transporter (NET) that has demonstrated efficacy in the treatment of children with attention-deficit hyperactivity disorder (ADHD). We investigated whether polymorphisms in the NET/SLC6A2 gene may influence atomoxetine response in ADHD. Two i...

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Veröffentlicht in:Neuropsychopharmacology (New York, N.Y.) N.Y.), 2009-08, Vol.34 (9), p.2135-2142
Hauptverfasser: Ramoz, Nicolas, Boni, Claudette, Downing, AnnCatherine M, Close, Sandra L, Peters, Sandra L, Prokop, Angela M, Allen, Albert J, Hamon, Michel, Purper-Ouakil, Diane, Gorwood, Philip
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Sprache:eng
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Zusammenfassung:Atomoxetine is a specific inhibitor of the norepinephrine transporter (NET) that has demonstrated efficacy in the treatment of children with attention-deficit hyperactivity disorder (ADHD). We investigated whether polymorphisms in the NET/SLC6A2 gene may influence atomoxetine response in ADHD. Two independent cohorts of 160 and 105 ADHD children treated for 6 weeks with atomoxetine (0.5–1.8 mg/kg per day) were genotyped on CYP2D6 , which metabolizes atomoxetine, and 108 single nucleotide polymorphisms in the NET/SLC6A2 gene. Response was defined as a minimum decrease of 25% in ADHD Rating Scale IV-Parent Version and a Clinical Global Impression-Severity (CGI-S) score less than or equal to 2 at week 6. Interindividual response was independent of the genetic variants of CYP2D6 . Significant ( p
ISSN:0893-133X
1740-634X
1470-634X
DOI:10.1038/npp.2009.39