Saponins as novel TNF-alpha inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Saponins as novel TNF-alpha inhibitors: isolation of saponins and a nor-pseudoguaianolide from Parthenium hysterophorus

Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-alpha. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with...

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Veröffentlicht in:Organic & biomolecular chemistry 2009-01, Vol.7 (16), p.3230-3235
Hauptverfasser: Shah, Bhahwal Ali, Chib, Renu, Gupta, Pankaj, Sethi, Vijay Kumar, Koul, Surrinder, Andotra, Samar Singh, Nargotra, Amit, Sharma, Sujata, Pandey, Anjali, Bani, Sarang, Purnima, Basant, Taneja, Subhash Chandra
Format: Artikel
Sprache:eng
Schlagworte:
Asteraceae - chemistry
Plant Extracts - chemistry
Saponins - isolation & purification
Sesquiterpenes, Guaiane - isolation & purification
Tumor Necrosis Factor-alpha - antagonists & inhibitors
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Zusammenfassung:Two novel saponins and a 13-nor-pseudoguaianolide designated as hysterolactone were isolated from Parthenium hysterophorus. The two saponins were found to be potent inhibitors of TNF-alpha. Their mode of inhibition was studied through molecular modeling. The wet lab results were in concordance with the data obtained from docking experiments.
ISSN:1477-0520
1477-0539
DOI:10.1039/b902041a