Letrozole as a booster therapy in growth hormone deficiency

Letrozole as a booster therapy in growth hormone deficiency

A 13 year old boy presented to us with short stature. Evaluation revealed growth hormone (GH) deficiency. He was treated with GH replacement for 10 months and to further boost up the growth potential, an aromatase inhibitor Letrozole was added to GH therapy. After one year of combination therapy, pa...

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Veröffentlicht in:Indian pediatrics 2009-07, Vol.46 (7), p.625-627
Hauptverfasser: Kumar, K V S Hari, Jayaraman, Muthukrishnan, Verma, Abhyuday, Modi, Kirtikumar D
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Aromatase Inhibitors - therapeutic use
Growth Disorders - drug therapy
Growth Hormone - deficiency
Humans
Male
Nitriles - therapeutic use
Triazoles - therapeutic use
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Zusammenfassung:A 13 year old boy presented to us with short stature. Evaluation revealed growth hormone (GH) deficiency. He was treated with GH replacement for 10 months and to further boost up the growth potential, an aromatase inhibitor Letrozole was added to GH therapy. After one year of combination therapy, patient had significant improvement in predicted adult height without a negative impact on pubertal progression.
ISSN:0974-7559