Benefit of angiographic spontaneous reperfusion in STEMI: does it extend to diabetic patients?

Background:Spontaneous reperfusion (SR) in ST elevation myocardial infarction (STEMI) improves clinical outcome, yet its incidence and impact among diabetic patients is unclear.Objective:To carry out a systematic analysis of SR in the diabetic cohort of a large primary percutaneous coronary interven...

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Veröffentlicht in:	Heart (British Cardiac Society) 2009-08, Vol.95 (16), p.1331-1336
Hauptverfasser:	Bainey, K R, Fu, Y, Granger, C B, Hamm, C W, Holmes, D R, O’Neill, W W, Seabra-Gomes, R, Pfisterer, M E, Van de Werf, F, Armstrong, P W
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Humanized Biological and medical sciences Cardiology. Vascular system Cardiovascular system Clinical outcomes Coronary Angiography - methods Coronary heart disease Diabetes. Impaired glucose tolerance Diabetic Angiopathies - diagnostic imaging Diabetic Angiopathies - mortality Diabetic Angiopathies - therapy Electrocardiography Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Heart Heart attacks Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Mortality Myocardial Infarction - diagnostic imaging Myocardial Infarction - mortality Myocardial Infarction - therapy Myocardial Reperfusion - methods Myocardial Reperfusion - mortality Myocarditis. Cardiomyopathies Patients Radiodiagnosis. Nmr imagery. Nmr spectrometry Remission, Spontaneous Single-Chain Antibodies Treatment Outcome Vasodilator Agents - therapeutic use
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Zusammenfassung:	Background:Spontaneous reperfusion (SR) in ST elevation myocardial infarction (STEMI) improves clinical outcome, yet its incidence and impact among diabetic patients is unclear.Objective:To carry out a systematic analysis of SR in the diabetic cohort of a large primary percutaneous coronary intervention (PCI)-treated population with STEMI.Methods and results:4944 patients (15.5% diabetic) undergoing primary PCI in the APEX AMI study were evaluated. SR defined as pre-PCI Thrombolysis in Myocardial Infarction (TIMI) 3 flow occurred in 11.5% of patients; it was more common in non-diabetic (11.9%) than in diabetic patients (9.2%) (p = 0.028). Patients with SR versus no SR had improved post-PCI TIMI 3 flow: in non-diabetic patients (99.8% vs 90.3%, p
ISSN:	1355-6037 1468-201X
DOI:	10.1136/hrt.2008.160390