The scent of Mycobacterium tuberculosis – Part II breath

The scent of Mycobacterium tuberculosis – Part II breath

Summary Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic...

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Veröffentlicht in:Tuberculosis (Edinburgh, Scotland) Scotland), 2009-07, Vol.89 (4), p.263-266
Hauptverfasser: Syhre, Mona, Manning, Laurens, Phuanukoonnon, Suparat, Harino, Paul, Chambers, Stephen T
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biomarkers - analysis
Breath
Breath Tests - methods
Female
Gas Chromatography-Mass Spectrometry
GC/MS-MS
Humans
Infectious Disease
Male
Metabolites
Methyl nicotinate
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - metabolism
Nicotinic Acids - analysis
Odorants - analysis
Pilot Projects
Pulmonary/Respiratory
SPME
Sputum - microbiology
Tuberculosis, Pulmonary - diagnosis
Young Adult
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Zusammenfassung:Summary Recent figures show that tuberculosis (TB) is advancing and killing more than two million people annually, yet no breakthrough in rapid diagnostics is in sight. Volatile metabolites of Mycobacterium tuberculosis (MTB) may provide just that. It is well established that MTB produces nicotinic acid in vitro . We have converted the free acid into methyl nicotinate and detected statistically significant differences in the breath of smear positive patients compared with healthy (smear negative) subjects.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2009.04.003