Rapid regulation of intestinal divalent metal (cation) transporter 1 (DMT1/DCT1) and ferritin mRNA expression in response to excess iron loading in iron-deficient rats

We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. DMT1 mRNA was down-regulated and Ft mRNA was up-regulated 2 h after administering the iron. However, more than 2 h...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2010, Vol.74 (3), p.655-658
Hauptverfasser:	Arita, A., Tokyo Metropolitan Univ., Hachioji (Japan), Tadai, K, Shinoda, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARN MENSAJERO ARN MESSAGER Biological and medical sciences Cation Transport Proteins - metabolism divalent metal transporter 1 (DMT1)/DCT1 Duodenum - drug effects Duodenum - metabolism excess iron EXPRESION GENICA EXPRESSION DES GENES FER FERRITIN FERRITINE Ferritins - metabolism Fundamental and applied biological sciences. Psychology GENE EXPRESSION HIERRO http://www.fao.org/aos/agrovoc#c_27527 http://www.fao.org/aos/agrovoc#c_29036 http://www.fao.org/aos/agrovoc#c_37715 http://www.fao.org/aos/agrovoc#c_3924 http://www.fao.org/aos/agrovoc#c_3950 http://www.fao.org/aos/agrovoc#c_4765 http://www.fao.org/aos/agrovoc#c_6258 http://www.fao.org/aos/agrovoc#c_6464 INTESTIN Intestinal Absorption INTESTINES INTESTINOS IRON Iron - deficiency Iron, Dietary - administration & dosage Male MESSENGER RNA METAL METALES METALS PROTEIN SYNTHESIS RAT RATA RATS Rats, Wistar RNA, Messenger - metabolism SINTESIS DE PROTEINAS SYNTHESE PROTEIQUE
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Zusammenfassung:	We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. DMT1 mRNA was down-regulated and Ft mRNA was up-regulated 2 h after administering the iron. However, more than 2 h was needed for Ft protein synthesis to occur in the duodenal mucosa.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.90721