Ringing the Changes: A Remarkable Carbene-Free Synthesis of Difluorocyclopropenes

Ringing the Changes: A Remarkable Carbene-Free Synthesis of Difluorocyclopropenes

The end is in sight for the use of difluorocarbene (generated from toxic or inconvenient heavy‐metal or gaseous reagents) in the preparation of geminal difluorocyclopropenyl compounds. A series of fluorinated alkynes now serve as precursors to these important small‐ring systems (e.g. see picture) th...

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Veröffentlicht in:Angewandte Chemie International Edition 2003-05, Vol.42 (21), p.2399-2401
Hauptverfasser: Brisdon, Alan K., Crossley, Ian R., Flower, Kevin R., Pritchard, Robin G., Warren, John E.
Format: Artikel
Sprache:eng
Schlagworte:
alkynes
cyclization
fluorine
small-ring systems
structure elucidation
synthetic methods
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Beschreibung
Zusammenfassung:The end is in sight for the use of difluorocarbene (generated from toxic or inconvenient heavy‐metal or gaseous reagents) in the preparation of geminal difluorocyclopropenyl compounds. A series of fluorinated alkynes now serve as precursors to these important small‐ring systems (e.g. see picture) through a remarkably facile and convenient transformation initiated by tert‐butyllithium.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200250756