GABA and endocrine regulation—Relation to neurologic-psychiatric disorders

Data obtained with experimental animals and with humans concerning the involvement of GABA-ergic systems in the control of hormonal secretion have been discussed and analyzed. The available evidence indicates that GABA-ergic systems might modulate the release of several hypothalamic-hypophyseal hormones that are involved in behavioral regulation, either via their endocrine actions or via their direct actions on the brain. Further studies along this line might lead to the development of GABA-ergic drugs that will be useful for treating certain hormonal or neuropsychiatric disorders.